Regenerative treatment of a post-remodeling acute myocardial infarct with HGF releasing mesenchymal stem cells encapsulated in OPF/GO hydrogel

Meer, Martijn, M.Y. van der (2020) Regenerative treatment of a post-remodeling acute myocardial infarct with HGF releasing mesenchymal stem cells encapsulated in OPF/GO hydrogel. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

This article focusses on a regenerative therapy post-AMI (Acute Myocardial Infarct). The therapy uses stem cells and a hydrogel to regenerate a new and healthy myocardium. An injectable OPF/GO hydrogel can provide structural integrity and conductivity for increased stem cell survival. Together with the capability of delivering biomolecules to the infarct zone. Included are proteins periostin and TGFβ. These could possibly return homeostasis in the infarcted tissue and reduce collagen through their ability to recruit MMP and TIMP releasing fibroblasts. The OPF/GO hydrogel will carry encapsulated mesenchymal stem cells (MSCs). Due to immune tolerance and the ability to differentiate into multiple cell types needed in cardiac repair, MSCs are a promising candidate for cardiac regeneration. It is demonstrated that MSCs can differentiate into cardiomyocytes in the human body making it viable for therapy. Combined with hepatocyte growth factor (HGF), the survival rate of MSCs is increased showing an enhancement of the cardiac function. In conclusion, the concept of an OPF/GO hydrogel with encapsulated MSCs combined with fibroblast recruiting factors can regenerate myocardium and possibly degenerate the fibrotic scar tissue. Improving cardiac function and decreasing morbidity.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Krenning, G.
Degree programme:	Biomedical Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	27 Jul 2020 14:01
Last Modified:	27 Jul 2020 14:01
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/22891

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