Boersma, Renzo (2020) Effectiveness of pharmacotherapy in obesity treatment: targeting the central nervous system and peripheral hormones. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
The prevalence of overweight and obesity has reached epidemic proportions over the last decades. Worldwide, more than 1.9 billion adults are overweight, of which over 650 million are obese; 39% and 13% of the total adult world population respectively. Obesity causes and exacerbates a wide spectrum of physical and mental conditions. Effective treatment of the disease has therefore been called for; however, finding a solution seems to be extremely difficult. There is a treatment gap between poor efficacy lifestyle modifications and invasive bariatric interventions, which pharmacotherapy could possibly overcome. We highlight the important role of the central nervous system and peripheral hormones, in feeding behaviour and energy homeostasis. The aim of the present essay was to answer the question whether targeting the central nervous system and peripheral hormones with pharmacotherapy is effective in the treatment of obesity. It can be concluded that steps are being made in the right direction regarding the use of pharmacotherapy in obesity treatment. Although there currently is not a single pharmacological drug effective in treating obesity when given as monotherapy, even a minor reduction of 5 – 10% in body weight already improves overall fitness and comorbidities. Further studies should focus on polytherapy, where multiple drugs are given in conjugation.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Scheurink, A.J.W. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 02 Aug 2020 10:00 |
| Last Modified: | 02 Aug 2020 10:00 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/22955 |
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