Lietz, Morten Peter (2020) 'Connecting the Dots’ - Reduced Frontoparietal Theta Connectivity in Subjective Cognitive Decline. Research Project 2 (major thesis), Behavioural and Cognitive Neurosciences.
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Abstract
As the world’s population is increasingly ageing, the prevalence of Alzheimer’s disease (AD) is on the rise with 10 million new cases each year. In order to prolong the preclinical stages of the disease, the two dementia-risk stages Mild Cognitive Impairment (MCI) and Subjective Cognitive Decline (SCD) are most promising in terms of intervention and preventive treatment. Novel insight into the role of executive dysfunction along the AD trajectory provides an auspicious target for early detection methods such as executive task-dependent connectivity analysis using electroencephalogram (EEG). As frontoparietal theta oscillations have been proposed to be the working language of executive functions (EF), which are fundamental for independent everyday living, this empirical study investigated changes in coherence estimates between the dorsolateral-prefrontal cortex (DLPFC), the frontal midline (FM) region and the parietal cortex during EF tasks of memory updating, conflict monitoring and motor inhibition in healthy controls (HC), MCI and SCD patients. In order to assess memory updating, conflict monitoring and motor inhibition, EEG recorded N-Back, Stroop, and Stop Signal tasks were used. Due to exclusion criteria, no EEG data was obtained for the MCI group, however, lower levels of theta band coherence between the DLPFC and FM were observed in the SCD group in contrast to HC during the memory updating task.
| Item Type: | Thesis (Research Project 2 (major thesis)) |
|---|---|
| Supervisor name: | Enriquez Geppert, S. and Flores Vazquez, J.F. |
| Degree programme: | Behavioural and Cognitive Neurosciences |
| Thesis type: | Research Project 2 (major thesis) |
| Language: | English |
| Date Deposited: | 31 Aug 2020 07:31 |
| Last Modified: | 31 Aug 2020 07:31 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/23292 |
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