Nijhuis, Dave, (2020) Inhibiting p53 degradation to combat aging. Bachelor's Thesis, Biology.
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Abstract
Mouse Double Minute 2 (MDM2) functions as a negative regulator of tumor protein p53 by promoting degradation through ubiquination. Research found that by inhibiting the p53/MDM2 interaction cells entered a senescence like state. Furthermore Wiley et al., (2018) found that a known MDM2 antagonist named Nutlin-3a was able to attenuate the Senescence-associated Secretory Penotype (SASP). This might reduce the aging process in organisms as the SASP is mostly recognized as pro-inflammatory. In this thesis I argue that, while the attenuation of the SASP looks promising, the p53/MDM2 inhibition will not slow aging but might even speed up the process.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Linskens, M.H.K. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 01 Sep 2020 13:03 |
| Last Modified: | 01 Sep 2020 13:03 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/23316 |
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