Yu, Jiawei (2020) The Reproductive Origin of the Autism Spectrum Disorder: An Immunological Point of View. Master's Thesis / Essay, Behavioural and Cognitive Neurosciences.
|
Text
mBCN_2020_YuJ.pdf Download (1MB) | Preview |
|
![[img]](https://fse.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
toestemming.pdf Restricted to Registered users only Download (152kB) |
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder featured with dysregulations in social interaction, communication and repetitive behavior. Prenatal exposure to some factors is associated with increased ASD incidences in human studies, such as endocrine-disrupting chemicals, infections etc. In this review, we try to integrate the prenatal risk factors and investigate their contribution to the pathogenesis of ASD. These factors can elicit maternal immune activation (MIA) and increase the circulating cytokines in the fetus, which primes the fetal microglia for enhanced inflammatory responses, thereby more susceptible to a second challenge later. The heightened inflammatory responses induced by MIA are termed innate immune memory (IIM), implicated in microglia. Treatment targeting the IIM such as colony-stimulating factor 1 receptor (CSF1R) inhibitors can correct the ASD-like behaviors in rodent MIA offspring. Taken together, the paper suggests that MIA mediates the relationship between some prenatal risk factors and the pathogenesis of ASD. The framework offers a unified understanding of the reproductive origin of ASD. Future animal studies should also focus on combining MIA and a second challenge with different nature, timing and severity (two-hit model) to determine a sufficient combination for the development of ASD and other neurodevelopmental disorders.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Plosch, T. and Olivier, J.D.A. |
| Degree programme: | Behavioural and Cognitive Neurosciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 28 Sep 2020 11:43 |
| Last Modified: | 28 Sep 2020 11:43 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/23439 |
Actions (login required)
 |
View Item |