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Trophic and toxic effects of iron balance in multiple sclerosis: from remyelination to neurodegeneration

Lioutas, Vasileios (2020) Trophic and toxic effects of iron balance in multiple sclerosis: from remyelination to neurodegeneration. Master's Thesis / Essay, Medical Pharmaceutical Sciences.

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Abstract

While iron is essential for physiological cellular brain functions such as normal mitochondrial function and remyelination, increased cerebral iron depositions have been linked to neurodegenerative disorders and particularly Multiple Sclerosis. Data from MRI and histological studies have found increased deposits of iron in the brain of patients with MS and specifically in macrophages and microglia, two types of central nervous system cells that are directly implicated in MS pathoetiology. This essay focuses on and discusses the role of iron balance in MS pathophysiology as well as on the physiologically significant role of iron within cells for oxidative metabolism and remyelination, thus offering insight into the trophic and toxic effects of brain iron levels.

Item Type: Thesis (Master's Thesis / Essay)
Supervisor name: Eisel, U.L.M.
Degree programme: Medical Pharmaceutical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 16 Oct 2020 08:03
Last Modified: 16 Oct 2020 08:03
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/23497

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