Paro, I (2020) Selective modulation of TNF-TNFR signalling for amelioration in experimental autoimmune encephalitis. Master's Research Project 1, Biomedical Sciences.
|
Text
mBMS_2020_ParoI.pdf.pdf Download (2MB) | Preview |
|
![[img]](https://fse.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
toestemming.pdf Restricted to Registered users only Download (166kB) |
Abstract
Multiple sclerosis is an autoimmune, demyelinating, neurodegenerative disease. One of the prominent targets in modulating the inflammation in MS patients is tumor necrosis factor-α (TNF-α). TNF is a master cytokine involved in maintaining immune system homeostasis in the body but more importantly, increased levels have been correlated with MS in patients. Furthermore, TNF comes in two distinct forms, which bind to two different receptors that have different functions. TNF receptor 1 is involved in pro-inflammatory pathways and activated caspase-mediated cell death. TNF receptor 2 is responsible for cells survival and has been implicated in neuroprotection and immunosuppression via regulatory T cells. Through modulation of both receptors with a TNFR1 antagonist and a TNFR2 agonist, we expect an ameliorated disease course in the mouse model for MS. Analysis of secondary lymphoid tissues and their immune cell compositions will be used to explore the mechanism by which therapeutic effect is achieved. Investigation of different immune cell populations and their movements during the disease state can elucidate new possible targets and also help in explaining the MS immunopathology.
| Item Type: | Thesis (Master's Research Project 1) |
|---|---|
| Supervisor name: | Eisel, U.L.M. and Pegoretti, V. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Research Project 1 |
| Language: | English |
| Date Deposited: | 04 Jan 2021 11:21 |
| Last Modified: | 04 Jan 2021 11:21 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/23757 |
Actions (login required)
 |
View Item |