Schretlen, SMMA (2021) The effect of Liquid-Liquid Phase Separation on the DNA damage response to double-stranded breaks. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
One of the hallmarks of cancer is genomic instability, which encompasses a high rate of genetic alterations during cell division. To ensure proper cell function and faithful transmission of the genome to progeny, cells have evolved sophisticated and strict mechanisms that accurately respond to DNA insults thereby either repairing the affected DNA or drive the cell into apoptosis, summarized as the DNA damage response (DDR). Recently, the emerging topic of membraneless organelles, formed by the process liquid-liquid phase separation (LLPS) is also implicated to be involved in the DDR. LLPS encompasses the process in which molecules, due to their intrinsic disordered properties, can undergo rapid transitions in phase either by self-assembly or by interactions with other proteins. LLPS plays a major role in the formation of DNA damage foci, which are compartmentalized droplets comprising of secondary DDR factors that stimulate proper DNA repair.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Vugt, M.A.T.M. van |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 05 Jan 2021 10:40 |
| Last Modified: | 05 Jan 2021 10:40 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/23779 |
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