Quantification of Perfusion using QASPER Phantom

Ganesan, Seshasai (2021) Quantification of Perfusion using QASPER Phantom. Master's Thesis / Essay, Biomedical Engineering.

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Abstract

In this research project, the Arterial Spin Labelling technique was used to study and quantify perfusion and the reproducibility of the values in the Quantitative Arterial Spin Labelling Perfusion Reference (QASPER) Phantom. The FAIR PASL incorporating the QUIPSS II saturation pulse technique was used for labelling of the spins. The perfusion was quantified using the widely accepted PASL CBF formula ad parameters, presented in the white paper for ASL Implementation. Voxel wise analysis of the Phantom was done in the different perfusion discs and the perfusion values based upon different flow rate settings of 100, 200, 300, 400, 450, and 485 ml/min were calculated and compared. The results showed that with the parameters set for the experiment, while they were in the acceptable range according to the white paper, there were large deviations and a high degree of over quantification of the perfusion than stated in the phantom documentation. An increasing trend in the values of the perfusion was observed for each flow rate in every disc. The flow dynamics within the phantom layers was also studied to justify the results in the trend. While the results did not concur with the values stated in the phantom documentation, further modifications of the ASL technique and understanding of transit times in the phantom may be helpful in improving the results of this study.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Renken, R.J.
Degree programme:	Biomedical Engineering
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	29 Jan 2021 13:38
Last Modified:	29 Jan 2021 13:38
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/23856

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