Structural information of protein targets of Chlamydia trachomatis and Treponema pallidum

Simons, Charlotte (2020) Structural information of protein targets of Chlamydia trachomatis and Treponema pallidum. Bachelor's Thesis, Pharmacy.

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Abstract

Here, the atomic structure of potential protein targets of C. trachomatis and T. pallidum are presented, which provide insight into the disease mechanism and host interactions by using a variety of imaging techniques. The three-dimensional structure of proteins will show how molecules are assembled, how they interact, and how they function. The crystal structures of different proteins are created using PyMOL (DeLano Scientific) and are inter alia visualized in a cartoon format. Besides, the electrostatic surface presentation shows potential ligand-binding sites of the protein. The potential function of different proteins is investigated by using the Protein Data Bank (PDB) code to detect structural homologs. Also, ligand-protein interactions are analyzed by 2D-diagrams, which are generated by LigPlot. The structural information provides possibilities in the discovery of potential protein targets to combat a chlamydia or syphilis infection. Overall, these data elucidate how structural information has led to a clearer understanding of disease mechanisms, which can lead to the development of treatments for chlamydia and syphilis.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Groves, M.R.
Degree programme:	Pharmacy
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	02 Feb 2021 15:29
Last Modified:	02 Feb 2021 15:29
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/23901

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