Comparative analysis of synthetic strategies for the histone deacetylase inhibitor largazole from Caldora penicillata An integrative literature review

Simoin, M.A. (2021) Comparative analysis of synthetic strategies for the histone deacetylase inhibitor largazole from Caldora penicillata An integrative literature review. Bachelor's Thesis, Pharmacy.

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Abstract

According to reports provided by the World Health Organization, cancer is the second leading cause of death, accounting for approximately 9.6 million deaths in 2018. A prognosticated global increase of cancer cases among the population can be attributed to various risk factors mainly associated with the increasing age of the population. To counteract this tendency, there is a great demand for new medications to prevent or to treat cancer. In search of that, natural products are considered as promising candidates, representing potential leads for new drug developments. Cyanobacteria produce a large deviation of secondary metabolites due to their ability to survive in different biotopes Among them, largazole, a cyclic depsipeptide produced by Caldora penicillata, gained increased attention due to its observed bioactivity as class I histone deacetylase (HDAC), inhibiting the process of cell division. The bio-synthesis of largazole in Caldora penicillata is proposed to function via a hybrid NRPS/PKS pathway. Herein, a comparative analysis of available and possible synthetic strategies to synthesize the natural product largazole under economic and environmental aspects is reported. Therefore, recent literature on largazole found on searching tools as Pubmed, Scifinder and Smartcat were used. The results show that the highest yield could be obtained via the total synthesis pathways. This will be compared to a semi-approach based on the four pre-cursor building blocks of largazole f

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Schmidt, S. and Runda, M.E.
Degree programme:	Pharmacy
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	05 Mar 2021 15:22
Last Modified:	05 Mar 2021 15:22
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/24045

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