Electrostatic complexation between oppositely charged block-type glycopolymers

Benninga, Joël (2021) Electrostatic complexation between oppositely charged block-type glycopolymers. Master's Thesis / Essay, Chemistry.

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Abstract

Glycopolymers (i.e. macromolecules bearing pendant saccharide units) have attracted considerable attention, particularly in the field of drug delivery, due to their biocompatibility and capability of molecular recognition with lectins. Furthermore, glycopolymers can be produced from naturally occurring sugars and in a controlled fashion with tailored molecular weight, structure, functionality, and even sequencing. Although glycopolymer self-assembly and even drug delivery have been reported before, only one article has been published on the self-assembly of oppositely charged glycopolymers. The electrostatic interactions of polyelectrolytes – macromolecules carrying multiple charges – often dictate their physical properties, including self-assembly. When two oppositely charged polyelectrolytes are mixed in solution, interpolyelectrolyte complexes are typically formed due to cooperative electrostatic interactions. Therefore, the goal of this master’s thesis was to explore the formation of glycosylated nanoparticles through electrostatic interactions between block-type glycopolymers of opposite charges.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Loos, K.U. and Bozorg, M. and Pelras, T.W.L.A.A.
Degree programme:	Chemistry
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	23 Mar 2021 12:59
Last Modified:	23 Mar 2021 12:59
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/24111

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