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Characterization of secondary malignancies in patients diagnosed with Chronic Lymphocytic Leukemia

Ordelman, Valeska (2021) Characterization of secondary malignancies in patients diagnosed with Chronic Lymphocytic Leukemia. Research Project 1, Biomedical Sciences.

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Abstract

Chronic lymphocytic leukemia (CLL) is the most frequent type of leukemia in the Western world. CLL can be distinguished by the presence of a clonal expansion of CD5+CD23+ B-cells in the bone marrow, blood, and secondary lymphoid tissue. Important in the pathogenesis of CLL is the activation of CLL cells, which has a B-cell receptor (BCR) gene signature. Moreover, there is also an important role for immune dysregulation in the pathogenesis of CLL. Additionally, there was also shown that CLL patients have a high level of genetic mutability and some of these mutations even have prognostic value. There is an enhanced prevalence of secondary malignancies in CLL patients which include mostly skin malignancies, but also other solid tumors and hematological malignancies occur. The origin of a secondary malignancy in CLL patients seems to be multifactorial, including shared genetic and environmental risk factors as well as a dysregulated immune system. The aim of this study is to elaborate a hypothesis to explain biologically the association between CLL and secondary malignancies using clinical data from CLL patients with secondary malignancies. Therefore, the patient data base of the University Medical Centre Groningen was reviewed and patients diagnosed with CLL and a secondary malignancy were selected. From these 84 patients, variables were collected about patient characteristics, CLL and the secondary malignancy. Thereafter, the data was organized and analyzed. Results showed tha

Item Type: Thesis (Research Project 1)
Supervisor name: Schuringa, J.J. and Bellido Casado, M.
Degree programme: Biomedical Sciences
Thesis type: Research Project 1
Language: English
Date Deposited: 06 Apr 2021 09:34
Last Modified: 06 Apr 2021 09:34
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/24166

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