Is time all we need for COPD?

Vries, Klaas de (2021) Is time all we need for COPD? Bachelor's Project, Pharmacy.

Preview	Text Bachelor project COPD.pdf Download (1MB) | Preview
	Text toestemming.pdf Restricted to Registered users only Download (120kB)

Abstract

COPD is a prime cause of death worldwide with many elderly people suffering from it. While this is a big problem no efficient treatment is available. The only treatment so far is to relieve the symptoms which are wheezing, cough, mucus production and difficulty breathing. The main issue is the destruction and impaired repair of lung epithelial cells, specifically in the lung alveoli. Due to the epithelial damage, the elasticity of the lungs decreases and so increase the force necessary to inhale and exhale. The alveoli are important for the gas exchange between CO2 and O2 with air and blood, when these are severely damaged or inflamed there is emphysema. All of these factors contribute to the symptoms of COPD. While no current treatment is efficient for COPD a new novel mechanism might be the solution. The biological master clock in the brain has been known for quite some time however, a more recent finding is that peripheral cells individually also contain a biological clock. This biological clock shows disruptions in COPD with most noticeable a general decrease in NR1D1 and an overall increase in SIRT1. This postulates the hypotheses that NR1D1 and SIRT1 are key in the aberrant epithelial-mesenchymal cell interaction with fibroblasts driving emphysema. So maybe the best medicine is simply time.

Item Type:	Thesis (Bachelor's Project)
Supervisor name:	Gosens, R.
Degree programme:	Pharmacy
Thesis type:	Bachelor's Project
Language:	English
Date Deposited:	07 Apr 2021 09:21
Last Modified:	07 Apr 2021 09:21
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/24199

Actions (login required)

View Item