Salmonella-based cancer therapy and the stabilizing methods.

Wang, Tianyang (2021) Salmonella-based cancer therapy and the stabilizing methods. Bachelor's Thesis, Pharmacy.

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Abstract

Bacteria plays an important role in maintaining homeostasis. The human microbiota can induce and prevent oncogenesis at the same time. Various genetically engineered salmonella (VNP20009, A1-R and ∆ppGpp) have been proven effective against cancer. Salmonella-mediated bacterial therapy has great potential due to their diversified mechanism of actions including the direct killing of cancer cells via inducing apoptosis and autophagy pathway; specifically targeting and accumulating in tumor; stimulating the immune system in the body and around the tumor; being used as a vector to deliver various anti-cancer agents; inhibiting angiogenesis; reducing drug resistance by reducing the abundance of p-glycoprotein; combining with and improving the efficacy of chemotherapy and radiotherapy. Two potential stabilization methods freeze-drying and foam drying of salmonella are described.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Hinrichs, W.L.J.
Degree programme:	Pharmacy
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	07 Apr 2021 15:08
Last Modified:	07 Apr 2021 15:08
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/24202

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