It's about time – the role of the biological clock in chronic lung disease, COPD

Saleh, Roaa (2021) It's about time – the role of the biological clock in chronic lung disease, COPD. Bachelor's Project, Pharmacy.

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Abstract

Chronic obstructive pulmonary disease is one of the main causes of death nowadays, which is characterized by chronic bronchitis and emphysema, and it is mainly caused by cigarette smoke. In this disease, the epithelium is impaired, the lung stem cell progenitors do not work as they should, and they cannot repair the damaged lung tissue. The circadian rhythm system has been reported to play essential roles in the development of COPD. Circadian rhythms are biological oscillations in mammals with a period of around 24 h driven by the biological clock system. All cells in the human body have their own circadian clocks controlled by a central circadian clock located in the SCN in the hypothalamus. This system has vital roles in the regulation of different body events. In this thesis COPD cell atlas website was used to identify the role of the biological clock in COPD and clarify the core clock genes expression in COPD lungs compared to the control lungs. The results showed that the expression of these genes was different in COPD lungs than in control lungs. The most interesting result was regarding the CRY1 gene. This gene was increased in the airway cells in COPD while its expression was decreased in AT2A cells. AT2 cells can differentiate into AT1 cells with the help of different signaling pathways, such as WNT/B-catenin signaling. The results also indicated that CRY1 gene was strongly expressed in alveolar cells in control lungs compared to other core clock genes.

Item Type:	Thesis (Bachelor's Project)
Supervisor name:	Gosens, R.
Degree programme:	Pharmacy
Thesis type:	Bachelor's Project
Language:	English
Date Deposited:	07 Apr 2021 09:32
Last Modified:	07 Apr 2021 09:32
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/24212

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