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Novel therapeutic strategies for idiopathic pulmonary fibrosis: targeting epithelial repair and regeneration

Baalman, Leo (2021) Novel therapeutic strategies for idiopathic pulmonary fibrosis: targeting epithelial repair and regeneration. Bachelor's Thesis, Pharmacy.


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Idiopathic pulmonary fibrosis (IPF) is a progressive respiratory disease in which excessive scarring and impaired epithelial regeneration declines lung function. Because currently used drugs do not cure IPF, the need for more effective and safe drugs is still urgent. Opportunities may lie at specific epithelial targeting by interfering with growth factor signaling, or by using gene therapy. Despite extensive performed research on fibrotic pathways, current knowledge regarding treatment strategies which target epithelial repair in IPF is still limited. We therefore summarized the most potent findings of 4 strategies (TGF-β, FGF, miRNA, TERT) with differently working mechanisms on the lung epithelium. In this review, we will introduce IPF and elaborate its pathophysiology. We then discuss the individual involvement of the four mediators in IPF and evaluate studies which performed interventions or investigated treatment options, after which recommendations for future research are provided in order to address the faced challenges regarding pleiotropic mediator functions as well as development of drug and model design. Addressing these remarks will provide better or even curing treatment options in the near future for this severe and pathologically complex disease.

Item Type: Thesis (Bachelor's Thesis)
Supervisor name: Ruigrok, M.J.R.
Degree programme: Pharmacy
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 09 Apr 2021 14:41
Last Modified: 09 Apr 2021 14:41

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