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Association of antihypertensive medication and severity of Dupuytren's disease

Bergen, S. van (2021) Association of antihypertensive medication and severity of Dupuytren's disease. Research Project 1, Biomedical Sciences.


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Dupuytren’s disease (DD) is a common, fibroproliferative disorder of the palmar fascia that causes flexion deformities of the fingers. It is a complex disease caused by both genetic and environmental factors and has an incompletely understood aetiology. Transforming growth factor beta 1 (TGFβ1) plays an important role in the disease mechanism of DD. Recently, angiotensin II was discovered to modulate TGFβ1 production. We thus hypothesised angiotensin II blockers could be associated with the severity of DD. The aim of this study was to investigate the effect of angiotensin receptor blockers (ARBs) and angiotensin converting enzyme inhibitors (ACEi) on the severity of DD. This retrospective study used a database of 1761 DD patients, including data on patient’s clinical characteristics, medication use, flexion deformity clinimetrics, and genotype data. Ordinal logistic regressions were performed to study the association between ARBs or ACEi and DD severity (defined in Tubiana stages). The regression analysis showed a significant negative association between ARB use and DD severity, ACEi’s did not show a significant association. In conclusion, we observed a significant association between ARBs and DD severity. This study may provide new insights into medication and DD severity. The results of this study may be used to develop new and improved therapies for treating DD.

Item Type: Thesis (Research Project 1)
Supervisor name: Bank, R.A. and Riesmeijer, S.A.
Degree programme: Biomedical Sciences
Thesis type: Research Project 1
Language: English
Date Deposited: 02 Jun 2021 12:27
Last Modified: 02 Jun 2021 12:27

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