Animal models in research examining stem cell therapy for human lung disease: a support in the quest to develop therapies

Slot, Karlijn (2021) Animal models in research examining stem cell therapy for human lung disease: a support in the quest to develop therapies. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

Acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD) are lung diseases characterized by severe inflammation. No cures are identified for these diseases yet. Stem cell treatment is suggested to be a valid option for these patients, but examination of these models is needed. Animal models are used for drug testing and validating treatments. However, it is discussed which part of the ARDS/COPD pathology is adequately modelled by animal models and whether current modelling is sufficient for making clinical translation possible. This review is aimed to identify whether the use of animal models as step in research towards stem cell therapy for human lung disease (ARDS and COPD) is an utopia, a need, or a support in the quest to develop therapies. It is shown that a generalized and optimized model for both diseases is needed. The absence of comprehensive ARDS and COPD animal models has led research to develop new in vitro models in order to examine stem cell treatment and its underlying mechanisms. These in vitro models, as lung organoids and lung-on-a-chip models, sound promising but are not optimized yet. To conclude: there is a need for optimizing the in vivo and in vitro models for ARDS and COPD in order to examine the underlying mechanisms of MSC-treatment for these diseases. Thus, animal models (and in vitro models) are a support in the quest to develop therapies and the first step needed now is optimization of these models.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Harmsen, M.C.
Degree programme:	Biomedical Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	14 Jun 2021 13:30
Last Modified:	14 Jun 2021 13:30
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/24564

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