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Diagnosis of Liver Fibrosis with Bacterial Biomarkers

Stavast, Mirthe (2021) Diagnosis of Liver Fibrosis with Bacterial Biomarkers. Bachelor's Thesis, Pharmacy.

Bachelor Research Project, Mirthe Stavast, S3714756.pdf

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Introduction: Diagnosis of liver fibrosis often comes too late, resulting in only one treatment option: liver transplantation. As liver fibrosis causes (almost) no symptoms in the early stages and most diagnostic tools focus on advanced liver fibrosis, there is a high need for early diagnostic tools. The interaction between the liver and the intestine in liver diseases becomes of more interest in the latest research. However, is it also possible to use this interaction for the diagnosis of liver fibrosis? Moreover, can a bacterial biomarker from the blood or stool be used as a diagnostic tool for liver fibrosis in stage F1 or F2 of the disease? Results: It is more likely that a biomarker for liver fibrosis can be found in stage F2 of the disease, instead of stage F1. There are specific changes in phyla (Proteobacteria, Actinobacteria, Fusobacteria and Bacteroidetes) that might be of interest in this research. Also, the concentration of 16S rDNA in the blood might be used for the early diagnosis. Conclusion: It can be concluded that it might be possible to diagnose liver fibrosis in stage F2 of the disease, using a bacterial biomarker in the blood and in the stool of patients. Further research is necessary, but the findings are extremely promising.

Item Type: Thesis (Bachelor's Thesis)
Supervisor name: Poelstra, K.
Degree programme: Pharmacy
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 18 Jun 2021 14:04
Last Modified: 18 Jun 2021 14:04

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