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Computational modelling of scaffolds for interfacial tissue engineering

Rikmanspoel, Timo (2021) Computational modelling of scaffolds for interfacial tissue engineering. Research Project 1, Biomedical Sciences.

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Abstract

In the human body, hard soft-tissue interfaces are the connections between hard and soft tissues such as tendon and bone. They are composed of different mechanical and biochemical properties, and while the connection is strong, it still remains prone to injuries. The bone-tendon hard-soft tissue interface consists of 4 zones with different mechanical properties. The gradual change in properties helps with better transferring the load during movement. In my study I aim at developing scaffolds that mimic the native gradient structure in hard-soft tissue interface. For scaffold production, Melt Electrowriting (MEW) is used to produce fibrous scaffolds from polycaprolactone (PCL). Scaffolds with different designs were printed, including designs with gradually changing architecture. To examine if the scaffolds are suitable for hard-soft tissue applications, mechanical tests on the scaffolds were performed (e.g. tensile test). However, these tests are mostly destructive methods. Therefore, in this research, to support experimental data, computer simulations in COMSOL were established. With the use of these simulations, mechanical properties of the scaffolds can be predicted. These computer simulations can be a powerful tool to save both time and materials. Finally, cell culture was performed to examine if the proposed scaffolds are relevant for application in regenerative medicine.

Item Type: Thesis (Research Project 1)
Supervisor name: Harmsen, M.C.
Degree programme: Biomedical Sciences
Thesis type: Research Project 1
Language: English
Date Deposited: 12 Jul 2021 08:36
Last Modified: 12 Jul 2021 08:36
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/25107

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