Progress in diagnosing ABPA in patients with CF by using biomarkers and recombinant allergens

Koning, Linda (2021) Progress in diagnosing ABPA in patients with CF by using biomarkers and recombinant allergens. Bachelor's Thesis, Biology.

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Abstract

Aspergillus fumigatus is an opportunistic fungus responsible for Allergic Bronchopulmonary Aspergillosis (ABPA), often also seen in patients with cystic fibrosis (CF) (Nikolaizik et al., 1991). The disease is progressive, and there is often difficulty with diagnosis, ultimately leading to respiratory failure. Diagnosis is difficult due to many reasons, including overlapping symptoms and no official agreement for cut-offs with criteria, leading to differences between clinics (Zirbes & Milla, 2008). This thesis describes the need for progress in diagnostic criteria as well as two relatively new methods that seem to be promising. Fricker-Hidalgo et al., sheds light on using recombinant antigen rAspf4 detection against IgE, which gave significant results with high sensitivity. IgE levels are one of the most important criteria in diagnosing ABPA in CF patients, thus new types of criteria are also sought after. Keown et al., describes the usage of measuring exhaled nitric oxide levels in children with CF to diagnose ABPA, leading to significant results and promising new information for more accurate diagnostic criteria in the future.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Gosens, R. and Ciminieri, C.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	09 Jul 2021 13:55
Last Modified:	09 Jul 2021 13:55
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/25128

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