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The effects of aerobic and non-aerobic exercise regimes on muscular insulin resistance

Post, Milan (2021) The effects of aerobic and non-aerobic exercise regimes on muscular insulin resistance. Bachelor's Thesis, Biology.


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Lifestyle-related diseases are increasing in tandem with the obesity epidemic. One of the biggest challenges facing public health is the increase in type 2 diabetes. Type 2 diabetes is an often preventable, lifestyle related metabolic disorder. The normal insulin-response to hyperglycemia is impaired, leading to a chronic hyperglycemia and in turn a hyperinsulinemia. The mechanistic cause for this insulin resistance is often multifactorial; an aberrant signal transduction and inability to properly act on signalling pathways, abnormal lipid profiles and mitochondrial dysfunction are at play. A sedentary lifestyle contributes to the further development of insulin-resistance and metabolic disorders. Physical activity and especially a regimented exercise routine can improve insulin sensitivity; promoting muscle remodeling for better nutrient delivery, improving receptor and post receptor signalling function as well as improving mitochondrial function. Aerobic exercise can be divided into moderate intensity, high volume and high-intensity, low volume training. Both forms offer similar adaptive benefits. Resistance training offers similar, but distinct benefits in relation to insulin sensitivity. A combination of both aerobic and resistance training offers the greatest benefits for insulin sensitivity.

Item Type: Thesis (Bachelor's Thesis)
Supervisor name: Kruit, J.K.
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 26 Jul 2021 09:33
Last Modified: 26 Jul 2021 09:33

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