The Control of the Biological Clock Beyond Transcription

Postma, Leanne (2021) The Control of the Biological Clock Beyond Transcription. Bachelor's Thesis, Life Science and Technology.

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Abstract

The master regulator of the biological clock, located in the suprachiasmatic nucleus, synchronizes all physiological processes to the environment. The basis of the molecular circadian clock is a transcription-translation feedback loop where certain proteins inhibit their own transcription. The molecular mechanisms underlying this circadian rhythm go beyond transcription because they are regulated via post-transcriptional mechanisms and epigenetics as well. Involved post-transcriptional mechanisms are splicing events, RNA interference via micro RNAs, and the controlling of poly(A) tail lengths of clock gene transcripts. Besides that, NOC and SR proteins play a role in the regulation of the circadian rhythm. Furthermore, epigenetics is crucial for generating a circadian rhythm via RNA methylation and histone acetylation. All these mechanisms should be linked to each other in order to get a full understanding of the biological clock and to make it of clinical relevance.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Havekes, R.
Degree programme:	Life Science and Technology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	20 Jul 2021 13:17
Last Modified:	20 Jul 2021 13:17
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/25348

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