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Targeting TNFR2 in Alzheimer's Disease

Hooijsma, A.A. (2021) Targeting TNFR2 in Alzheimer's Disease. Research Project 1, Biomedical Sciences.

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Abstract

Upon ageing, the risk for developing Alzheimer’s Disease (AD) increases. As the population ages, the interest in curing this disease rises. Within AD, inflammation plays an important role during its pathogenesis, whereby tumour necrosis factor α (TNF) is considered a major contributor. When released, TNF can bind to tumour necrosis factor receptor (TNFR)1, inducing inflammation and neurodegeneration and TNFR2 enhancing neuroprotection. Regarding its protective role, this study aims to analyse the effect of TNFR2 stimulation on neuroinflammation in a humanized AD’s mouse model. For analysing the effect in human context, a crossbreed between J20 mice and mice with a human knock-in TNFR2 was treated with a selective mouse TNF-based agonist of TNFR2 (STAR2) whereby treatment with PBS was used as a control. The results showed that STAR2 induced a significant decrease in microglia in hippocampal areas cornu ammonus (CA)1, CA3 and the dentate gyrus (DG). A significant decrease in microglial activity was found in the DG upon STAR2 treatment. Concerning astrocytes, no significant differences were found. Regarding these results, it can be concluded that treatment with STAR2 may contribute to reducing inflammation in AD.

Item Type: Thesis (Research Project 1)
Supervisor name: Eisel, U.L.M. and Orti Casan, N.
Degree programme: Biomedical Sciences
Thesis type: Research Project 1
Language: English
Date Deposited: 23 Jul 2021 11:52
Last Modified: 23 Jul 2021 11:52
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/25425

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