Eijk, S van (2021) Treatment of Autism spectrum disorder by targeting the gastrointestinal system. Bachelor's Thesis, Life Science and Technology.
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Abstract
Autism spectrum disorder (ASD) is characterized by social and communicational difficulties, accompanied by restricted and repetitive behavior. This asks for suitable therapy options. ASD is tied to several comorbidities, one of them being gastrointestinal (GI) symptoms. ASD incidence is influenced both by genetics and environment. Current treatment options consist of both pharmacological and nonpharmacological interventions. Since ASD often co-occurs with gut disturbances, a new prospective for treatment can be found in the gut-brain axis (GBA). The GBA is a bidirectional communicational mechanism between gut and brain. It involves pathways through the nervous systems of the gut and the brain, neuroendocrine pathways, immunological pathways, and bacterial metabolite pathways. GI abnormalities like atypical metabolite production, increased gut permeability, increased serotonin production and maternal factors are hypothesized to have a contribution in ASD incidence. Possible ASD therapies that target GI issues are fecal microbiota transplantation (FMT), pro- and prebiotics and dietary interventions. Although positive effects have been reported for these therapies, effects were small, and extensive studies were limited. More research is necessary to establish if these treatments possibly can become conventional.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Scheurink, A.J.W. |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 09 Aug 2021 09:02 |
| Last Modified: | 09 Aug 2021 09:02 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/25618 |
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