The long lasting symptoms of the COVID-19 pandemic

Feitsma, E (2021) The long lasting symptoms of the COVID-19 pandemic. Bachelor's Thesis, Life Science and Technology.

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Abstract

COVID-19 has heavily affected almost all countries in the world. It has already been around for more than 18 months since the first discovery in Wuhan, China in late 2019 and it has infected more than 175 million people and is accountable for almost 4 million victims worldwide. Persistent symptoms related to COVID-19 are commonly seen in people that recovered from the SARS-CoV-2 infection and can vary significantly between individuals, similar to the symptoms experienced during the acute phase of COVID-19. Early data from hospitalized people showed a common seen characteristic in these individuals with severe COVID-19, this commonly seen characteristic are comorbidities. Lung transcriptome data from people with comorbidities like chronic obstructive pulmonary disease and hypertrophy, often seen together in patients with severe COVID-19, showed a significant increase in ACE2 expression, the crucial host receptor for SARS-CoV-2 binding and entry. This suggests that people with comorbidities have an increased chance of developing a more severe COVID-19. Another study showed that people with comorbidities, and a high symptom load during acute COVID-19, are associated with an increased chance of developing long lasting COVID-19 related symptoms. Also, some people with severe COVID-19 are treated similar to people with ARDS, this might cause additional pulmonary damage in some individuals and worsen the rehabilitation, as some develop an atypical form of ARDS. Understanding which people in the population are vulnerable to COVID-19 helps to develop strategies to protect them and decrease the societal damage caused by SARS-CoV-2 or a potential future viral outbreak.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Gosens, R. and Ciminieri, C.
Degree programme:	Life Science and Technology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	17 Aug 2021 08:48
Last Modified:	17 Aug 2021 08:48
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/25715

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