Luxwolda, M (2021) Mechanisms of increased infection risk by sleep deprivation. Master's Thesis / Essay, Behavioural and Cognitive Neurosciences.
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Abstract
Sleep and immunity are two complex processes that interact on many levels. Adaptive responses to an infection are increased fatigue and sleepiness. Conversely, sleep deprivation in a healthy situation can have detrimental effects on the risk of infection. The potential mechanisms behind the effect of sleep deprivation on increased infection risk are complex and versatile. To provide an overview of current knowledge in this field, four sub questions are addressed. In general it can be stated that sleep counteracts low-grade inflammation, thereby maintaining immune homeostasis. Sufficient homeostasis of the immune system fails when sleep is disturbed, and mild inflammation may escape protection and the condition may worsen. Prolonged sleep loss increases the risk of reaching a chronic inflammatory status, which in turn has a disturbing effect on sleep. The negative interplay between sleep and the immune system then feeds into a vicious circle. Given that sleep has initial control over a healthy situation, makes it a valuable means of supporting immunity.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Havekes, R. |
| Degree programme: | Behavioural and Cognitive Neurosciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 28 Sep 2021 09:01 |
| Last Modified: | 28 Sep 2021 09:01 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/26135 |
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