Arici, Büşra (2021) Nanomedicine and Drug Targeting Applications to Cross the Blood Brain Barrier (BBB). Master's Thesis / Essay, Medical Pharmaceutical Sciences.
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Abstract
A very effective blood-brain barrier (BBB) protects and isolates the brain from general circulation. Endothelial cells with tight connections, high enzymatic activity, and efflux transport systems characterize this barrier. As a result, the BBB is intended to allow the selective movement of chemicals required for brain function. Some small lipophilic drugs diffuse enough through the BBB to be therapeutically effective. Many potentially beneficial medications, on the other hand, cannot. This barrier poses a significant problem for treating central nervous system illnesses that need therapeutic medication levels entering the brain. This paper provides an overview of the BBB structure and several ways to overcome the difficulty of drug transport at the BBB and ensure efficient delivery of therapeutic substances to the brain, emphasizing nanoparticles (NPs) as drug carriers. To better understand the ideas of brain medicine administration, the architecture and physiology of the BBB and its transport mechanisms are discussed. The use of NPs targeting the transporter systems that already exist on the BBB to transport nutrients has been suggested as one way to overcome BBB impermeability and improve selectivity and medication delivery to the brain. Various methods of transport through the BBB and ways to target specific routes are discussed. Additionally, NP strategies to reduce circulatory clearance and lengthen the time a medicine interacts with the BBB are discussed.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Salvati, A. |
| Degree programme: | Medical Pharmaceutical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 15 Nov 2021 15:33 |
| Last Modified: | 15 Nov 2021 15:33 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/26286 |
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