Bouwman, Lisa (2021) Could caffeine be used to treat cognitive impairments in Alzheimer’s disease? Master's Thesis / Essay, Biomedical Sciences.
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Abstract
Cognitive impairments are one of the main symptoms of Alzheimer’s disease (AD). There is currently no long-term treatment that reverses these cognitive impairments in AD, and the approved drugs do not target the pathology directly. Interestingly, epidemiological studies have found an association between caffeine consumption and a reduced risk of developing AD. Furthermore, caffeine is thought to be a cognitive enhancer. Since caffeine is found in many foods and drinks that are consumed on a daily basis, caffeine might be an efficient treatment for cognitive symptoms in AD. This review summarizes studies about the effects of caffeine on cognition and memory in both humans and rodents. Furthermore, the effects of caffeine on learning and memory in animal models of AD will be discussed, as well as the molecular mechanisms underlying these effects. In conclusion, caffeine could potentially be an efficient treatment for cognitive impairments in AD that might not only improve cognitive symptoms, but also act on the pathology directly by increasing amyloid-beta clearance and inhibiting neuroinflammation. Although there is no clear evidence that caffeine improves cognition in healthy humans, it seems to prevent and reverse memory impairments in animal models of AD. Investigation of the effects of caffeine on cognition in patients with AD is a crucial next step to gain more insight in the possibility of caffeine as a treatment for Alzheimer’s disease.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Havekes, R. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 23 Dec 2021 11:35 |
| Last Modified: | 23 Dec 2021 11:35 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/26413 |
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