Galectin-3 induced fibrotic response, generic or cell specific?

Geerlings, Lotte (2022) Galectin-3 induced fibrotic response, generic or cell specific? Master's Research Project 2, Biomedical Sciences.

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Abstract

Hallmarks which are shared in both cancer and cardiovascular disease include inflammation and fibrosis, which both play an important role in the pathophysiology of the diseases. One fibrosis biomarker which is both related to cancer and heart failure is galectin-3. Galectin-3 is a key player in the formation of fibrosis, specifically myocardial fibrosis and neoplastic stromal deposition. Fibrosis has been hypothesized to initiate cancer onset through the disruption of the tumour microenvironment, and galectin-3 has also been indicated to downregulate T-cell activation which could facilitate tumour growth. Galectin-3 is therefore an interesting target in both cancer and heart failure. The main cellular effectors of fibrosis are the myofibroblasts, which are modulated fibroblasts. Both genetic and pharmacological inhibition of galectin-3 has been shown to prevent cardiac remodelling in mouse and rat models, but inhibition of galectin-3 has yet to be researched in vitro. Therefore, this research project focused on the role of galectin-3 mediated fibrosis in different types of fibroblasts, and postulate whether this is a generic reaction or cell specific. Furthermore, this research will include a pilot murine study with the intention of creating a functional 6-week-old transaortic constriction mouse model to use for galectin-3 inhinition research.

Item Type:	Thesis (Master's Research Project 2)
Supervisor name:	Jong, S. de
Degree programme:	Biomedical Sciences
Thesis type:	Master's Research Project 2
Language:	English
Date Deposited:	15 Mar 2022 15:08
Last Modified:	15 Mar 2022 15:08
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/26696

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