Sinha, Yashi (2022) Insights into the Development of Antiviral Therapies for Influenza and New Nanoparticle-based Approaches of Treatment. Bachelor's Thesis, Life Science and Technology.
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Abstract
Influenza (the flu) is an annual respiratory illness that has resulted in a lot of societal burden. Presently, the first-line option to provide immunity against the virus is vaccination. However, due to the constantly mutating proteins on the virus, new vaccines have to be developed very frequently and this may not be a cost-effective option. Due to this, there has been an increasing interest in the usage of antiviral drugs for immediate treatment of influenza. One of the major disadvantages of using antivirals, however, is the emergence of strains that can become resistant to the available conventional drugs which is why extensive research is still being conducted in this area. This review provides an overview of the conventional drugs that have been in use, combination therapies, other advances in the creation of drugs that target various parts of the viral protein, and antibody-based therapies. Furthermore, the implications of a few nanoparticle-based approaches of treatment are also briefly discussed. To tackle the problem of drug resistance, combination therapies using the conventional drugs have been studied and have shown better results when compared to individual drug therapy. Antibody-based therapies with monoclonal antibodies that target the hemagglutinin protein of the virus have also shown encouraging results. With the advent of nanomedicine, new strategies for smooth drug delivery with Chitosan, Selenium and Silver nanoparticles are being investigated.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Huckriede, A.L.W. and Akkerman, R. |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 25 Apr 2022 07:36 |
| Last Modified: | 25 Apr 2022 07:36 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/26977 |
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