Veldkamp, Neel (2022) Concomitant Use of Oxycodone and Clarithromycin in the Netherlands: a utilization study using the IADB. Bachelor's Research Project, Life Science and Technology.
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Abstract
Oxycodone is a widely used analgesic opioid. In the Netherlands it is used for chronic pain management and short-term pain reduction. Oxycodone is metabolized by CYP3A4 into its inactive metabolites. The antibiotic, clarithromycin blocks the CYP3A4 enzymes, causing a decreased clearance of oxycodone and an increased chance of side effects. Therefore, this study aimed to investigate the extent of concomitant use of clarithromycin and oxycodone in the Netherlands. The data used in this study was retrieved from the IADB, a pharmaceutical database with patient and prescription data. In this study chronic oxycodone users over the age of 18 were evaluated, investigating concomitant use of oxycodone and clarithromycin and dosage changes after this concomitant use between 2001 and 2020. An incidence was formulated as concomitant use per 1,000 oxycodone users. Chi square test was used to test differences in concomitant use between the sexes. Dosage change was evaluated using a one sample t-test on a logarithmic scale. In this studies population, 616 counts of concomitant use were found, this equaled an incidence of 11.68 per 1,000 oxycodone users. The incidence has a declining trend over the years. The incidence of men and women differ significantly. The dosage change seems to be increasing after concomitant use, however more research is advised. Overall, it can be concluded that concomitant use has become less likely to occur on an individual level between 2001 and 2020.
| Item Type: | Thesis (Bachelor's Research Project) |
|---|---|
| Supervisor name: | Bijlsma, M.J. |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Research Project |
| Language: | English |
| Date Deposited: | 27 Jun 2022 12:13 |
| Last Modified: | 27 Jun 2022 12:13 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/27389 |
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