Kooi, Philip (2022) Inhibition of the cellular uptake of positively charged liposomes by HeLa cells and the different uptake mechanisms involved. Bachelor's Project, Pharmacy.
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Abstract
Aim: The aim of this study is to get a better understanding of the uptake by HeLa cells of positively charged liposomes, how can these pathways be inhibited and to what extent are they involved in the uptake. Methods and materials: 5 inhibitors were selected and exposed over time to the HeLa cells and measured for liposomal uptake using flow cytometry. Drug efficacy was measured by the measuring fluorescence. Results and conclusion: The results were interpreted using FlowJo and it was demonstrated that the uptake is more actin-dependent than microtubule-dependent and for macropinocytosis and clathrin-mediated endocytosis no clear conclusion could be drawn
| Item Type: | Thesis (Bachelor's Project) |
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| Supervisor name: | Salvati, A. and Reker-Smit, C. |
| Degree programme: | Pharmacy |
| Thesis type: | Bachelor's Project |
| Language: | English |
| Date Deposited: | 27 Jun 2022 12:42 |
| Last Modified: | 27 Jun 2022 12:42 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/27409 |
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