Process, Effects, Detection Methods and Possible Solutions for Reduction of Radicals, and ROS after Post-Ischemic Reperfusion Damage

Otter, Marith E. den (2022) Process, Effects, Detection Methods and Possible Solutions for Reduction of Radicals, and ROS after Post-Ischemic Reperfusion Damage. Bachelor's Thesis, Life Science and Technology.

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Abstract

Post-ischemic reperfusion damage is an often occurring problem after limited or stopped blood flow. There are a multitude of factors that play a role, one of which is oxidative stress caused by generation of radicals and reactive oxygen species (ROS). Knowledge about generation and detection of these radicals and ROS is plenty. However, few solutions have been found for this problem so far, and none that are working perfectly. In order to help patients that suffer from post-ischemic reperfusion damage, the aim of this thesis was to research the process, effects, detection methods and possible solutions for reduction of radicals, and ROS. Electron spin resonance spectroscopy, certain fluorescent techniques, certain spectrophotometric methods, and fingerprinting are discussed as detection methods. From these detection methods fingerprinting was determined to be the most promising and effective detection method as it assesses the damage that is done by the radicals instead of the radicals themselves. A post-ischemic enriched environment, radical trapping, manganese-porphyrin (MnP) complexes, and antioxidant systems are discussed as possible solutions, with a combination of antioxidant systems and the MnP complexes being the most promising. This because the body’s own way to fight oxidative stress is by using its antioxidant systems. Since it can take some time to alter these defence systems MnP complexes can be used to reduce any damage caused by the oxidative stress up until th

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Schirhagl, R.
Degree programme:	Life Science and Technology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	28 Jun 2022 14:12
Last Modified:	28 Jun 2022 14:12
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/27428

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