Ramesh, Vajrasri (2022) DEVELOPMENT AND OPTIMIZATION OF A BIOCOMPATIBLE HYDROGEL FOR SKIN REGENERATION COMPOSITES. Master's Internship Report, Biomedical Engineering.
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Abstract
Tissue engineered skin substitutes have evolved tremendously in the past couple of years and newer procedures are being developed every day to generate skin substitutes for clinical applications. These skin substitutes have been finding widespread application, especially in the case of burns and skin-related disorders where the major limiting factor is the availability of autologous skin. With the improvement of tissue engineering technology, the use of artificial skin to repair various skin defects and wounds is slowly moving into the clinic. The key to this technology however, lies in the development of dermal substitutes. Hence, the main focus in developing a skin substitute is to mimic the dermal layer of the skin. Although, to this date, a complete functional skin substitute in which the dermis can vascularize rapidly is not available. One of the important components in mimicking the dermis is the hydrogel that is used for the skin regeneration composite. The main properties of the hydrogel that make it essential for incorporation into the scaffold include biocompatibility, good stability and modulus, ability to form a homogenous gel and cost-effectiveness. Therefore, this research focuses on the development and optimisation of a biocompatible hydrogel for the skin regeneration composites.
| Item Type: | Thesis (Master's Internship Report) |
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| Supervisor name: | Wlodarczyk-Biegun, M.K. and Harmsen, M.C. |
| Degree programme: | Biomedical Engineering |
| Thesis type: | Master's Internship Report |
| Language: | English |
| Date Deposited: | 12 Jul 2022 10:19 |
| Last Modified: | 12 Jul 2022 10:19 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/27618 |
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