The controversial role of cellular senescence in the development of cancer

Sissing, Rick Abel Henk (2022) The controversial role of cellular senescence in the development of cancer. Bachelor's Thesis, Biology.

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Abstract

Cellular senescence is a hallmark of aging characterized by a stable, irreversible cell cycle arrest, which can be induced by various stimuli. For example, telomere shortening, DNA damage, and oncogenic signaling. Key features of senescent cells are the enhancement of gene expression, morphological changes, and chromatin reorganization. Numerous studies have been demonstrating the paradoxical role of cellular senescence. These studies have both shown how senescence might have a role in the development of cancer and its prevention of it. At first, senescence was thought to be a potent anticancer mechanism, because when tumor cells enter a senescent state they stop being able to proliferate. Also, the feature senescent-associated secretory phenotype, better known as SASP is known to induce senescence and cause the stop of the proliferation of tumor cells. However, growing evidence suggests that this characteristic of cellular senescence, the SASP, is involved in the positive promotion of tumor cells. In this article, the controversial role of cellular senescence in the development of cancer is discussed.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Bruggeman, S.W.M.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	12 Jul 2022 10:16
Last Modified:	12 Jul 2022 10:16
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/27720

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