Hydrophobic Drug Intercalation in Layered Double Hydroxides

Sevciuc, Anastasia (2022) Hydrophobic Drug Intercalation in Layered Double Hydroxides. Bachelor's Thesis, Life Science and Technology.

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Abstract

One of the challenges of modern biomedicine and biomedical engineering is hydrophobic drug delivery. The issues connected with hydrophobic agents, such as low bioavailability, inherent toxicity, and limited administration methods. However, considering the large number of antitumor agents and steroid drugs that have great treatment efficiency for the target problem, the need for a proper method of hydrophobic drug delivery is a relevant topic of research. This paper presents an overview of challenges connected to the delivery of hydrophobic agents and delivery systems previously used for them. The work focus then moves towards Layered Double Hydroxides, a type of anionic clays, and describes their properties and synthesis methods. The overview of the LDHs is followed by the description of their advantages that would be favorable for hydrophilic drug delivery, as proof that LDHs are a potent drug delivery system. The main topic is addressed in the sections containing the examples of studies focused on designing a method of intercalation of hydrophobic drugs in LDH layers. All described works are analyzed for on their advantages and limitations in the Discussion section, which also involves prospects for future research. The Conclusion section provides an overview of all work and summarizes all new suggestions brought up in the paper.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Rijn, P. van
Degree programme:	Life Science and Technology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	31 Mar 2023 11:56
Last Modified:	31 Mar 2023 11:56
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/27755

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