Al-Alyan, Zainab (2022) Using the PDGFB-receptor as a target for anti-fibrotic therapies. Research Project, Pharmacy.
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Abstract
Liver fibrosis is characterized by accumulation of extracellular matrix (ECM). When hepatic stellate cells are activated, they will contribute to the formation of ECM and thereby contribute to fibrosis. To target the progression of liver fibrosis, the PDGFB-receptor can be used since it is highly expressed in hepatic stellate cells. This thesis focusses on using a peptide, pPB-HSA, which specifically targets the PDGFB-receptor. Fibroferon will also be used which consists of the anti-fibrotic cytokine interferon gamma (IFNy) coupled to pPB. The cytoflex will be used to study the binding of pPB-HSA and Fibroferon to 3T3 cells which has not been done before. Together, these experiments can find a possible therapy to treat liver fibrosis.
| Item Type: | Thesis (Research Project) |
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| Supervisor name: | Poelstra, K. and Salvati, A. |
| Degree programme: | Pharmacy |
| Thesis type: | Research Project |
| Language: | English |
| Date Deposited: | 22 Jul 2022 14:52 |
| Last Modified: | 22 Jul 2022 14:52 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/28103 |
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