Koopmans, Marthe (2022) Maternal Serotonin System, Maternal Care, and Offspring Risk for Neuropsychiatric Disorders. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
Despite extensive research, no effective treatments have been developed for the highly comorbid neuropsychiatric disorders depression, anxiety, ADHD, and ASD. A potential denominator in their etiology is the serotonergic system, as serotonin (5-HT) plays an essential role in neurodevelopment and the maturation of circuitries related to these disorders. Maternalfetal interactions may influence 5-HT levels in the early fetal brain. Moreover, the maternal 5- HTergic system may affect downstream effects of brain development and potentially affect behavior in offspring. Serotonin also plays a role in maternal care which affects offspring’s behavior. Therefore, this essay aimed to examine how the maternal 5-HTergic system influences maternal care and the development of neuropsychiatric disorders in offspring. In rodents, the maternal serotonergic system is able to influence maternal care. In addition, offspring receiving low maternal care showed increased anxiety- and depressive-like behavior. Yet, in humans, association studies between maternal care and the serotonin transporter linked polymorphic region (5-HTTLPR) gene variance are inconsistent, and links between the maternal serotonergic system and neuropsychiatric disorders in offspring are not robust. However, parenting in humans is more complex than in rodents, so future studies could focus on different types of parenting to further explore the relationship between maternal care and neuropsychiatric disorders in offspring. Also, as many receptors are involved in serotonin signaling and the development of neuropsychiatric disorders, future research should further explore possible receptors and mechanisms involved in parental care to provide more information for potential treatments and minimize the risk of neuropsychiatric disorders in offspring
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Olivier, J.D.A. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 04 Aug 2022 07:46 |
| Last Modified: | 17 Aug 2022 10:05 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/28125 |
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