Knol, Loran (2022) Investigating the neural substrate of cognitive control in remitted depression with ACT-R and fMRI. Master's Thesis / Essay, Computational Cognitive Science.
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Abstract
Rumination, a key component of depression, is linked to a lack of cognitive control, and still present in remitted depressed patients. Rumination and cognitive control are also associated with medial and lateral frontoparietal networks, respectively. The connection between these networks turns out to be disturbed in people with remitted depression, but is unclear whether this disturbance contributes to their lack of cognitive control. To investigate this issue, healthy controls and remitted depressed patients were scanned in an fMRI scanner during a verbal working memory task. Afterwards, we applied preventive cognitive therapy (PCT), which expectedly alleviates rumination, to some of the remitted patients. Three months later, all remitted depressed patients performed the task again in the scanner. PCT is known to prevent relapse risk, but the expectation that this prevention is caused by an alleviation of rumination has never been confirmed. To test this expectation, we created ACT-R models that did the same task with and without rumination, but due to a poor data fit, the results were inconclusive. The fMRI scans were compared cross-sectionally, and healthy controls were found to have increased left inferior parietal lobule activation. No differences were found between treated and untreated remitted depressed patients. Spatial independent component analyses provided no evidence for a change in the inter-network connection with treatment.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Vugt, M.K. van |
| Degree programme: | Computational Cognitive Science |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 02 Aug 2022 07:02 |
| Last Modified: | 02 Aug 2022 07:02 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/28234 |
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