Stiensma, Berrit (2022) Hypokinetic Dysarthria in Advanced Parkinson’s Disease: Treatment Effects of Dopaminergic Medication and Deep Brain Stimulation. Research Project 2 (major thesis), Behavioural and Cognitive Neurosciences.
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Abstract
Motor symptoms in Parkinson’s disease (PD) can be effectively improved by dopaminergic medication and deep brain stimulation of the subthalamic nucleus (STNDBS). However, the impact of these therapies on hypokinetic dysarthria is still controversial. The objective is therefore to elucidate the impact of dopaminergic medication therapy and DBS on hypokinetic dysarthria in PD on an acoustic level. Semi-spontaneous speech of 37 patients with PD was recorded in two conditions: once before morning intake of dopaminergic medication and directly following dopaminergic administration. A subgroup of the PD participants (n = 9) underwent a third measurement after at least 6 months of bilateral STN-DBS. Additionally, speech of 37 healthy controls was recorded. Nine parameters representing speech dimensions that are affected in PD (i.e., tempo, prosody and voice quality) were extracted from the speech data using automatic acoustic voice analysis. These speech parameters were compared in three analyses: Parkinson vs. healthy controls, on-medication vs. off-medication and on-medication vs. DBS. Speech production of PD patients off-medication was found to be significantly worse than that of healthy controls. Further, the results revealed no difference between speech production of PD patients before and after dopaminergic medication administration. Lastly, speech parameters were not found to differ following DBS when compared to the on-medication state in PD patients. Speech production of PD
| Item Type: | Thesis (Research Project 2 (major thesis)) |
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| Supervisor name: | Brederoo, S.G. and Sommer, I.E.C. |
| Degree programme: | Behavioural and Cognitive Neurosciences |
| Thesis type: | Research Project 2 (major thesis) |
| Language: | English |
| Date Deposited: | 11 Aug 2022 12:28 |
| Last Modified: | 11 Aug 2022 12:28 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/28292 |
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