Boer, Jelle de (2022) Using Antibacterial Compounds in Synergy. Bachelor's Thesis, Biology.
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Abstract
In an effort to contain the ongoing increase in antibiotic resistance, research has been focusing on finding novel ways of employing existing antibiotics. One such line of research has emerged around the concept of drug combination to achieve synergistic effects such as enhanced antibacterial activity, resistance prevention and overcoming resistance. These objectives can be achieved through either combining antibiotics or combining an antibiotic with an antibiotic rejuvenating compound known as an adjuvant. Antibiotic combinations can be used to decrease the change of resistance development through increasing the amount of targeted gene products. Whereas adjuvants are usually used to overcome obtained or intrinsic resistance mechanisms, such as: inhibition of β-lactamases, inactivating antibiotic efflux pumps, or increasing the outer membrane permeability. This last example is of particular interest because it can be used to make previously ineffective antibiotics bactericidal against gram-negative bacteria. One major challenge is the translation of in vitro laboratory results into clinical practice. So far clinical success has been achieved with: isoniazid + rifampin against M. tuberculosis resistance, sulfamethoxazole + trimethoprim for enhanced antibacterial activity, and several β-lactam antibiotic + β-lactamase inhibitor combinations. But a lot of potential remains, demonstrated by the fast amount of synergistic combinations known from in vitro testing.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Kuipers, O.P. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | Dutch |
| Date Deposited: | 11 Aug 2022 12:48 |
| Last Modified: | 11 Aug 2022 12:48 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/28332 |
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