Pronk, Ines (2022) The role of microglia cells in Alzheimer’s disease, influence of ageing and a potential therapeutic target. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
Alzheimer’s disease is one of the most common forms of dementia and tremendously decreases the quality of life of millions of patients. The most profound hallmarks of AD are amyloid beta aggregates, tau neurofibrillary tangles, and neuroinflammation. It has been proposed that immunological mechanisms may play a key role in AD pathogenesis. It is thought that ageing influences the functioning of the immune system, and in particular microglial cells, which are the resident macrophages of the brain. These cells also appear to play a role in Alzheimer’s disease pathogenesis by causing persistent neuroinflammation, leading to neurodegeneration. As a result of the increasing prevalence of Alzheimer’s disease among elderly, the need to develop an effective treatment has also increased. The aim of this essay is therefore to elaborate further on the role of microglial cells in Alzheimer’s disease, how is ageing involved and can inflammatory factors be targeted for therapy. The most important aspects of this will be touched upon in this essay, from which it can be concluded that with advanced age, the functioning of microglia becomes impaired, leading to decreased phagocytosis of aggregated proteins and sustained neuroinflammation, contributing to AD pathogenesis. Additionally, the stimulation of the TNF receptor 2, is found to mitigate the neuropathological features of AD, making it a possible therapy for Alzheimer’s disease.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Eisel, U.L.M. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 14 Oct 2022 09:32 |
| Last Modified: | 14 Oct 2022 09:32 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/28842 |
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