Role of estrogen and endocrine disrupting chemicals in the development of non-alcoholic fatty liver disease in women

Oosterhout, Emily (2022) Role of estrogen and endocrine disrupting chemicals in the development of non-alcoholic fatty liver disease in women. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

One of the most prevalent chronic liver diseases, non-alcoholic fatty liver disease (NAFLD), is characterized by accumulation of fat in the liver. However, the reason why some people accumulate fat in the liver while others do not is poorly understood. The role of estrogen in the development of NAFLD has been under investigation in the past years, however the exact mechanisms in which estrogen exerts this protection is still unknown. Another factor, next to steroid hormones, that has been described to play a role in inducing NAFLD in both men and women is found in the environment. More specifically, a group of chemicals known to disrupt or alter the function of endocrine and metabolic organs such as the liver; endocrine disrupting chemicals. In this review the role of estrogen and estrogen like endocrine disruptors in the development of NAFLD in women is explored. Main results show that in males hepatic ERα plays a role in the development of liver steatosis after EEDC exposure. In females, EEDCs seem to directly influencing downstream regulators of hepatic lipid metabolism. Among other results, this concludes that the role of estrogen and EEDC exposure in the development of NAFLD in females is way more complex than in males. Multiple mechanisms of action that provide a link between EEDC exposure and NAFLD development are proposed in this review, however more research has to be performed to concluded if these mechanisms are true.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Koonen, D.P.Y.
Degree programme:	Biomedical Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	20 Oct 2022 10:28
Last Modified:	20 Oct 2022 10:28
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/28861

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