Hogenbirk, Jolijn Vivian Maria (2022) Sexual Behaviour in Male Serotonin Transporter Knockout Rats. Master's Research Project 2, Biomedical Sciences.
|
Text
Final Research Report Jolijn Hogenbirk S2890739.pdf Download (937kB) | Preview |
|
![[img]](https://fse.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
toestemming.pdf Restricted to Registered users only Download (378kB) |
Abstract
Premature ejaculation is the most common sexual dysfunction in males. This study aimed to investigate the effectiveness of on-demand treatment, combination therapy of a 5-HT1A antagonist (DU125530) together with SSRI (paroxetine) administration on sexual behaviour. The neurotransmitter serotonin plays an important role in social behaviour, including sexual behaviour. In general, it is stated that a decrease in serotonin facilitates sexual behaviour, while an increase in serotonin inhibits sexual behaviour. It is expected that sexual behaviour in rats with a lack of the serotonin transporter will be decreased. Results show that SERT-/- rats stabilize their sexual behaviour on a lower ejaculations frequency than the SERT+/+ rats do. However, both the SERT+/+ rats and the SERT-/- rats are able to stabilize their sexual behaviour after 1 week, Additionally, the latency until the first ejaculation is also longer for SERT-/- rats compared with the SERT+/+. These findings indicate that the sexual behaviour in the SERT-/- rats is lower than that of the SERT+/+ rats, with a consistent lower frequency of ejaculations for the SERT-/- rats compared with SERT+/+ rats. These results confirm previous findings which stated that serotonin plays a crucial role in sexual behaviour, indicating that a disrupted serotonin transporter, results in a reduced sexual behaviour, likely due to high levels of extracellular serotonin.
| Item Type: | Thesis (Master's Research Project 2) |
|---|---|
| Supervisor name: | Olivier, J.D.A. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Research Project 2 |
| Language: | English |
| Date Deposited: | 07 Dec 2022 13:04 |
| Last Modified: | 07 Dec 2022 13:04 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/29024 |
Actions (login required)
 |
View Item |