Could air pollution cause brain pollution? How ultra-fine particle air pollution is associated with Alzheimer's disease.

Barten, Alicia (2022) Could air pollution cause brain pollution? How ultra-fine particle air pollution is associated with Alzheimer's disease. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

Around 91% of the world’s population lives in areas where the air quality levels exceed the limits set by the World Health Organization (WHO) air quality guidelines. Previous studies have demonstrated that fine particle pollution (PM2.5) can be associated with cardiovascular disease, respiratory disease, and lung cancer. However, more recent studies indicated PM2.5 can be associated with neurodegenerative disease as well. To further elucidate the role of PM2.5 in the development of neurodegenerative disease and specifically Alzheimer’s Disease (AD) this essay analyzed a broad range of literature. This literary analysis demonstrated that PM2.5 exposure affects the CNS through different mechanisms that include: peripheral systemic inflammation, disruption of the blood-brain barrier, pathological abnormalities in of olfactory neurons and gut-microbiota brain axis alterations. Consequently, this leads to neuroinflammation, mitochondrial dysfunction, oxidative stress, and cell death. All of which have shown to play a crucial role in the pathophysiological process of AD as well. Due to the complexity and diversity of PM components, the development of AD is likely to result from multiple pathways and pathological interactions.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Eisel, U.L.M. and Jorna, L.M.
Degree programme:	Biomedical Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	02 Jan 2023 10:58
Last Modified:	02 Jan 2023 10:58
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/29099

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