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Report Research Project: The effect of diet on sucrose water intake in female Wistar rats

Huisjes, Hidde Jan (2023) Report Research Project: The effect of diet on sucrose water intake in female Wistar rats. Bachelor's Research Project (period 2a), Biology.


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Previous research has shown that exposure to a high-fat diet leads to increasing reward deficits and reward hyposensitivity, as well as a decreased dopamine turnover in rats. This has been suggested to lead to compensation through a compulsive increase in the intake of high-fat containing food. In this study, rats were put on a high-fat/sugar diet and measurements of sucrose water intake were taken in order to answer the research question “what is the effect of diet on the sucrose water intake of female Wistar rats?” and to subsequently provide evidence for the above-mentioned potential compensation. Our results have shown that, contrary to the hypotheses, rats on a high-fat diet showed a decreased sucrose water intake and a lower initial intake rate compared to rats on a LF diet. These contradicting findings might be explained by other studies indicating potential sex differences in food intake in response to a high-fat diet, since this study included female rats whereas the above-mentioned studies on reward sensitivity and dopamine turnover included male rats. In conclusion, female Wistar rats on a HF diet decrease the intake of sucrose water in addition to diet consumption compared to rats on a LF diet, which might be explained by the suggestion that total food intake is reduced during estrous.

Item Type: Thesis (Bachelor's Research Project (period 2a))
Supervisor name: Dijk, G. van
Degree programme: Biology
Thesis type: Bachelor's Research Project (period 2a)
Language: English
Date Deposited: 21 Mar 2023 15:36
Last Modified: 21 Mar 2023 15:36

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