Rietman, Gudo (2023) Killifish as a potential animal model for delirium investigation; comparison of its validity to currently used animal models. Bachelor's Thesis, Life Science and Technology.
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Abstract
Delirium is a common condition among ill elderly people, especially those with some degree of dementia. The acute onset of the disease is linked to a variety of triggers including precipitating and predisposing factors, often including systemic inflammation in the peripheral system. Currently however, the treatment of the underlying cause of delirium, and consequently treatment that would prevent delirium is impossible, as the pathophysiology of this disease is mostly unknown. However, investigation of the pathophysiology of delirium in human is difficult due to multiple reasons including physiological difficulties. Therefore it is inevitable to use animal models in researching delirium. Current research on delirium is being dune using mostly rodents as animal model, however, a promising animal to conduct research in is the killifish due to the fact that it is the shortest-lived vertebrate known to research, making it potentially highly suitable to conduct age-related research in. The primary aim of this thesis was to evaluate killifish as an option for an animal model for delirium. The findings of this thesis conclude that the utilization of killifish as an animal model for delirium research presents a promising avenue for researching delirium. This model affords the potential to serve as a cost-effective alternative to rodent models. However, it is important to note that substantial work still needs to be done in the design and validation of a killifish model that accuratel
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Laman, J.D. and Trzpis-Bremer, M. |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 16 May 2023 10:32 |
| Last Modified: | 16 May 2023 10:32 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/29742 |
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