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Optical Tweezers: Unfolding the Unknown

van der Molen, Aaltje (2023) Optical Tweezers: Unfolding the Unknown. Research Paper, Nanoscience.

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: Optical tweezers are a single-molecule characterization technique that can be applied in many fields. Though there are many biological applications for optical tweezers, one type of study that can be performed with optical tweezers is mechanical protein unfolding studies. This review paper focuses on the mechanical protein unfolding studies that have been performed. These studies can provide information on the folding pathway, intermediate states and misfolding of proteins. Specifically, slipknotted and knotted proteins can be investigated using optical tweezers. The function and folding pathway of these proteins are still unknown. Moreover, optical tweezers can be combined with surface-enhanced Raman spectroscopy to structurally characterize protein intermediates present at low concentrations.

Item Type: Thesis (Research Paper)
Supervisor name: Roos, W.H.
Degree programme: Nanoscience
Thesis type: Research Paper
Language: English
Date Deposited: 05 Jun 2023 12:18
Last Modified: 05 Jun 2023 12:18

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